Delivering on the Promise of Human Milk for Extremely Preterm Infants in the NICU (2024)

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    Editorial

    January 30, 2024

    Mandy BrownBelfort,MD, MPH1; MaryannePerrin,PhD, MBA, RDN2

    Author Affiliations Article Information

    • 1Department of Pediatrics, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts

    • 2Department of Nutrition, University of North Carolina, Greensboro

    JAMA. 2024;331(7):567-569. doi:10.1001/jama.2023.26820

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    • Original Investigation Donor Milk vs Formula and Neurodevelopmental Outcomes in Preterm Infants

      Tarah T.Colaizy,MD, MPH; Brenda B.Poindexter,MD, MS; Scott A.McDonald,BS; Edward F.Bell,MD; Waldemar A.Carlo,MD; Susan J.Carlson,MS, RD; Sara B.DeMauro,MD, MSCE; Kathleen A.Kennedy,MD, MPH; Leif D.Nelin,MD; Pablo J.Sánchez,MD; Betty R.Vohr,MD; Karen J.Johnson,RN, BSN; Dianne E.Herron,RN; AbhikDas,PhD; Margaret M.Crawford,BS; Michele C.Walsh,MD, MS; Rosemary D.Higgins,MD; Barbara J.Stoll,MD; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network; MILK Trial Investigators; Richard APolin; MartinKeszler; Angelita MHensman; ElisaViera; LucilleSt. Pierre; Robert TBurke; Barbara Alksninis; AndreaKnoll; Mary LKeszler; Teresa MLeach; Elisabeth CMcGowan; Victoria EWatson; Nancy SNewman; Bonny SSiner; AngeliaWilliams; ElizabethRoth; William ETruog; Eugenia KPallotto; CheriGauldin; Anne Holmes; Kathy Johnson; Allison Scott; LisaGaetano ; C MichaelCotten; Ronald NGoldberg; Ricki FGoldstein; Patricia LAshley; DeenaMago-Shah; JoanneFinkle; Kathryn EGustafson; Carl LBose; Janice Bernhardt; GennieBose; JaniceWereszczak; DianeWarner; Jennifer Talbert; RaviPatel; David PCarlton; Barbara JStoll; YvonneLoggins; DianeBottcher; Sheena LCarter; Ellen CHale; SalathielKendrick-Allwood; JudithLaursen; MaureenMulligan LaRossa; ColleenMackie; Amy Sanders; GloriaSmile; LynnWineski; Andrew ABremer; Stephanie Wilson Archer; Lu AnnPapile; Carolyn Lytle; Lucy Smiley; Leslie DawnWilson; DonnaWatkins; Susan Gunn; JeffJoyce; Jon ETyson; Amir MKhan; Ricardo AMosquera; EmilyStephens; Elizabeth Allain; Julie Arldt-McAlister; FatimaBoricha; KatrinaBurson; Allison GDempsey; CarmenGarcia; Donna JHall; Janice John; Patrick MJones; M LayneLillie; KarenMartin; Sara CMartin; Carrie MMason; Georgia E McDavid; Shannon LMcKee; Michelle Poe; KimberlyRennie; TinaReddy; Shawna Rodgers; SabaKhan Siddiki; Daniel Sperry; Patti LPierce Tate; Sharon LWright; Jonathan LSlaughter; ChristopherTiman; Keith OYeates; PatriciaLuzader; Nancy Batterson; HallieBaugher; Demi RBeckford; Stephanie Burkhardt; Helen Carey; Michelle Chao; CourtneyCira; ErnaClark; BrittanyDeSantis; ErinFearns; Christine AFortney; AubreyFowler; JuieGutentag; Jennifer LGrothause; Cole DHague; Sarah A Keim; Katelyn Levengood; LauraMarzec; Jacqueline McCool; Bethany Miller; Pamela Morehead; Mary AnnNelin; Julia Newton; Courtney Park; Lindsay Pietruszewski; JessicaPurnell; Julie CShadd; Kristi LSmall; MelanieStein; MargaretSullivan; Rox AnnSullivan; KyrstinWarnimont; LinaYossef-Salameh; Carla MBann; Marie GGantz; DennisWallace; JeanetteO’Donnell Auman; Annie Bayard; JennaGabrio; DavidLeblond; Jamie ENewman; Lindsay Parlberg; Carolyn MPetrie Huitema; Kristin MZaterka-Baxter; Monica VCollins; Shirley SCosby; Kirstin JBailey; Fred JBiasini; Stephanie AChopko; Kristy ADomnanovich; Chantel JJno-Finn; MorissaLadinsky; Mary BethMoses; Tara E McNair; Vivien APhillips; JuliePreskitt; Richard VRector; Kimberlly Stringer; SallyWhitley; ShereeYork Chapman; JohnWidness; Jane EBrumbaugh; Mendi LSchmelzel; Jacky R Walker; Claire A Goeke; Diane LEastman; Michelle LBaack; Megan MHenning; Chelsey Elenkiwich; Megan Broadbent; Sarah Van Muyden; Kristi LWatterberg; ConraBackstrom Lacy; Carol Hartenberger; Sandra Sundquist Beauman; Mary Hanson; Jean RLowe; ElizabethKuan; Eric CEichenwald; HareshKirpalani; Aasma SChaudhary; Toni Mancini; Judy CBerenbaum; MarshaGerdes; HallamHurt; Jonathan Snyder; SarithaVangala; KristinaZiolkowski; RonnieGuillet; Gary J Myers; SatyanLakshminrusimha; Holly I MWadkins; Michael GSacilowski; Melissa FCarmen; Rosemary L Jensen; Joan Merzbach; William Zorn; OsmanFarooq; AshleyWilliams; StephanieGuilford; KelleyYost; Melissa Bowman; Ann MarieScorsone; CaitlinFallone; KyleBinion; ConstanceOrme; PreminiSabaratnam; AlisonKent; RachelJones; Elizabeth Boylin; Daisy Roches; Emily Lillie; Jennifer Kachelmeyer; Kimberly GMcKee; Kelly RColeman; Karen Wynn; Michelle Hartley-McAndrew; NirupamaLaroia; Jeffrey Meyers; Luc PBrion; Diana MVasil; Sally SAdams; LijunChen; Maria M De Leon; FrancesEubanks; Rebecca McDougald; LaraPavageau; PollieannaSepulveda; AliciaGuzman; Elizabeth Heyne; Linda AMadden; Lizette ELee; KristineTolentino-Plata; CathyTwell Boatman; AzucenaVera; Jillian Waterbury; Amy Atok; DeniseWeuhausen; Elizabeth Brammer; CherylLaird; SeethaShankaran; AthinaPappas; Beena GSood; Melissa 44958; PrashantAgarwal; SanjayChawla; Rebecca Bara; KirstenChilds; Eunice Woldt; LauraGoldston; Stephanie AWiggins; Mary KChristensen; Diane FWhite; NamisavayamAmbalavanan,MD; Myra H.Wyckoff,MD; Carl T.D’Angio,MD; George W.Bugg,MD, MPH; Robin K.Ohls,MD; Anne MarieReynolds,MD, MPH; Gregory M.Sokol,MD; Abbot R.Laptook,MD; Steven L.Olsen,MD; Jessica R.White,MD; Sudarshan R.Jadcherla,MD; MonikaBajaj,MD; Prabhu S.Parimi,MD; BarbaraSchmidt,MD, MSc; Matthew M.Laughon,MD, MPH; JohnBarks,MD; Kimberley A.Fisher,PhD; Anna MariaHibbs,MD, MSCE; MyriamPeralta-Carcelen,MD, MPH; NoahCook,MD; Roy J.Heyne,MD; BrennaCavanaugh,PsyD; IraAdams-Chapman,MD; JanellFuller,MD; Michelle E.Hartley-McAndrew,MD; Heidi M.Harmon,MD, MS; Andrea F.Duncan,MD, MS; Abbey C.Hines,PsyD; Howard W.Kilbride,MD; Laurie A.Richards,MD; Nathalie L.Maitre,MD, PhD; GirijaNatarajan,MD; Andrea N.Trembath,MD, MPH; Martha D.Carlson,MD, PhD; William F.Malcolm,MD; Deanne E.Wilson-Costello,MD

      JAMA

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    From the moment of birth, infants born extremely preterm or at an extremely low birth weight (<1000 g) face critical illness due to multiorgan system immaturity, typically requiring hospitalization in the neonatal intensive care unit (NICU) for several months. Medical interventions now allow most of these infants to survive to hospital discharge, and the focus has shifted to identifying interventions that reduce adverse health and developmental consequences during childhood and beyond. With this goal in mind, the highly controlled NICU diet offers a feasible target for intervention, with the potential to optimize ex utero brain development during the critical period in the third trimester that coincides with the NICU hospitalization.

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    Belfort MB, Perrin M. Delivering on the Promise of Human Milk for Extremely Preterm Infants in the NICU. JAMA. 2024;331(7):567–569. doi:10.1001/jama.2023.26820

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